Numazaki K, Sakamoto Y, Umetsu M, Agatsuma Y, Yamanaka T, Kogasaka R, Hiraki

M, Kuniya Y, Miua J, Ukae S, Ueda D, Sato T, Chiba S

Department of Pediatrics, Sapporo Medical University School of Medicine,

Japan. numazaki@sapmed.ac.jp

Children infected with Chlamydia pneumoniae sometimes experience lower respiratory tract infections such as pneumonia and bronchitis. Although numerous anti-microbial compounds have been reported to be active against the organism, most of them have not been in a clinical trial in infants and children with C. pneumoniae infection. Clarithromycin has been shown to express anti-chlamydial effects in vitro. In this study, we evaluated the clinical anti-C. pneumoniae properties of clarithromycin in children with mainly lower respiratory tract infection. We administered clarithromycin orally to 21 infants and children at a dose of 10-15 mg/kg/day divided into two or three doses for 4-21 days. Clinical symptoms, roentgenographic and laboratory abnormal findings improved. The overall clinical efficacy rate was 85.7% (18 of 21 cases). Administration of clarithromycin was considered to be a suitable treatment for improving lower respiratory infections in infants and children caused by C. pneumoniae.

Publication Types: Clinical trial Multicenter study