■ 准教授
農学博士 久木田 明子 （くきた あきこ）
基礎研究棟2F 2211室 Tel. 0952-34-2246 Fax. 0952-34-2252
メール：
基礎研究棟2F 2211室 Tel. 0952-34-2246 Fax. 0952-34-2252
メール：
◆ 担当講義など
・全学 主題科目「分子生物学」
・医学部 主題科目「医学研究の勧め」
・医学科1年 細胞生物学I
・医学科2年 細胞生物学III
・医学科2年 微生物学
・医学科4年 PBLチューター
・医学科 選択コース「骨代謝免疫研究法」 ... 2週間 ☆ この実習の内容が学内新聞「Mudskippers」で紹介されています．
・看護学科1年 微生物学
・大学院医科学修士課程 病因病態学概論
・大学院医科学修士課程 微生物学・免疫学特論
・九州大学 客員教授 (2014年4月〜)
・医学部 主題科目「医学研究の勧め」
・医学科1年 細胞生物学I
・医学科2年 細胞生物学III
・医学科2年 微生物学
・医学科4年 PBLチューター
・医学科 選択コース「骨代謝免疫研究法」 ... 2週間 ☆ この実習の内容が学内新聞「Mudskippers」で紹介されています．
・看護学科1年 微生物学
・大学院医科学修士課程 病因病態学概論
・大学院医科学修士課程 微生物学・免疫学特論
・九州大学 客員教授 (2014年4月〜)
◆ 業績
Takano T, Li YJ, Kukita A, Yamaza T, Ayukawa Y, Moriyama K, Uehara N, Nomiyama H, Koyano K, Kukita T.
Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis.
Lab Invest. 2014 Mar;94(3):286-96.
Kukita A, Kukita T.
Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis.
Future Oncol. 2013 Nov;9(11):1609-22.
Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K, Kukita T.
Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
J Cell Biochem. 2013 Jun;114(6):1238-47.
Teramachi J, Kukita A, Qu P, Wada N, Li YJ, Nakamura S, Kukita T.
Adenosine blocks aminopterin-induced suppression of osteoclast differentiation.
J Bone Miner Metab. 2013 Jan;31(1):64-70.
Matsubara R, Kukita T, Ichigi Y, Takigawa I, Qu PF, Funakubo N, Miyamoto H, Nonaka K, Kukita A.
Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats.
PLoS One. 2012;7(10):e47930
Li YJ, Kukita A, Watanabe T, Takano T, Qu P, Sanematsu K, Ninomiya Y, Kukita T.
Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.
Lab Invest. 2012 Dec;92(12):1777-87.
Kukita A, Ichigi Y, Takigawa I, Watanabe T, Kukita T, Miyamoto H.
Infection of RANKL-Primed RAW-D Macrophages with Porphyromonas gingivalis Promotes Osteoclastogenesis in a TNF-α-Independent Manner.
PLoS One. 2012;7(6):e38500. Epub 2012 Jun 18.
Katagiri N, Shobuike T, Chang B, Kukita A, Miyamoto H.
The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
Microbes Infect. 2012 14(13):1123-1132.
久木田明子，菖蒲池健夫，久木田敏夫
破骨細胞の分化と機能を制御する転写因子の役割
化学と生物. 2012 50(7):488-497.
Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T, Pandolfi PP, Moriyama K, Takayanagi H.
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2561-6.
Kukita A, Kukita T, Nagata K, Teramachi J, Li YJ, Yoshida H, Miyamoto H, Gay S, Pessler F, Shobuike T.
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.
Arthritis Rheum. 2011 Sep;63(9):2744-54.
Teramachi J, Kukita A, Li YJ, Ushijima Y, Ohkuma H, Wada N, Watanabe T, Nakamura S, Kukita T.
Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis.
Lab Invest. 2011 May;91(5):719-31.
Moller JC, Cron RQ, Young DW, Girschick HJ, Levy DM, Sherry DD, Kukita A, Saijo K, Pessler F.
Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature.
Pediatr Rheumatol Online J. 2011 Feb 1;9(1):5.
Akiyama T, Miyamoto H, Fukuda K, Sano N, Katagiri N, Shobuike T, Kukita A, Yamashita Y, Taniguchi H, Goto M.
Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):669-76.
Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7.
Miyamoto I, Liu J, Shimizu K, Sato M, Kukita A, Kukita T, Kondo R.
Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
Eur J Pharmacol. 2009 5;602(1):1-7.
Li YJ, Kukita A, Teramachi J, Nagata K, Wu Z, Akamine A, Kukita T.
A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats.
Lab Invest. 2009 Jan;89(1):26-37.
久木田明子
”特集/骨免疫学は偶然か必然か？“ OCZF/LRFとそのホモログの破骨細胞とリンパ球における機能
骨・関節・靱帯 第20巻第8号 2007
K. Ogawa, M. Mawatari, M. Komine, M. Shigematsu, M. Kitajima, A. Kukita, T. Hotokebuchi
Mature osteoclasts involved in joint destruction are present in the synovium from patients with rapidly destructive coxarthrosis.
J. Bone and Miner. Metab. 25(6):354-30 2007
T. Fukuda, K. Kanomata, J. Nojima, I. Urakawa, T. Suzawa, M. Imada, A. Kukita, R. Kamijo, T. Yamashita, T. Katagiri
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.
Biochem. Biophys. Res. Comm. 353 p147-151 2007
Tang Q, Kukita T, Ushijima Y, Kukita A, Nagata K, Sandra F,Watanabe T, Toh K, Okuma Y, Kawasaki S, Rasubala L,Teramachi J,Miyamoto I, Wu Z, Iijima T
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds:successful supression of bone destruction accompanied with ajuvant-induced arthritis in rats.
Histochem. Cell Biol..125, NO.3, 215 2006
清水邦義、宮本以智子、塩野順、佐藤匡央、久木田明子、久木田敏夫、近藤隆一郎
マンネンタケ（Genoderma lucidum）エタノール抽出物による骨粗鬆症予防効果「機能性食品と薬理栄養」
日本機能性食品医用学会誌 VOL.4, NO.1, 29 2006年
Nakamura T, Kukita T, Shobuike T, Nagata K, Wu Z, Ogawa K, Hotokebuchi T, Kohashi O, Kukita A.
Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production.
J Immunol. 2005 Nov 1;175(9):5809-16.
Tang QY, Kukita T, Ushijima Y, Kukita A, Nagata K, Sandra F, Watanabe T, Toh K, Okuma Y, Kawasaki S, Rasubala L, Teramachi J, Miyamoto I, Wu Z, Iijima T.
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats.
Histochem Cell Biol. 2005 Oct 5:1-11
Kukita T, Wada N, Kukita A, Kakimoto T, Sandra F, Toh K, Nagata K, Iijima T, Horiuchi M, Matsusaki H, Hieshima K, Yoshie O, Nomiyama H.
RANKL-induced DC-STAMP is essential for osteoclastogenesis.
J Exp Med. 2004 Oct 4;200(7):941-6. Epub 2004 Sep 27.
Toh K, Kukita T, Wu Z, Kukita A, Sandra F, Tang QY, Nomiyama H, Iijima T.
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Lab Invest. 2004 Sep;84(9):1092-102.
Kukita T, Kukita A, Xu L, Toh K, Tang Q, Nomiyama H, Iijima T.
Extremely high expression of beta-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats.
J Electron Microsc (Tokyo). 2003;52(6):545-50.
Watanabe T, Kukita T, Kukita A, Wada N, Toh K, Nagata K, Nomiyama H, Iijima T.
Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL.
J Endocrinol. 2004 Jan;180(1):193-201.
Zheng CL, Ohki K, Hossain A, Kukita A, Satoh T, Kohashi O.
Complete Freund's adjuvant promotes the increases of IFN-gamma and nitric oxide in suppressing chronic arthritis induced by pristane.
Inflammation. 2003 Aug;27(4):247-55.
Rahman MM, Kukita A, Kukita T, Shobuike T, Nakamura T, Kohashi O.
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages.
Blood. 2003 May 1;101(9):3451-9. Epub 2003 Jan 2.
Zheng CL, Hossain MA, Kukita A, Ohki K, Satoh T, Kohashi O.
Complete Freund's adjuvant suppresses the development and progression of pristane-induced arthritis in rats.
Clin Immunol. 2002 May;103(2):204-9.
Sakai H, Jingushi S, Shuto T, Urabe K, Ikenoue T, Okazaki K, Kukita T, Kukita A, Iwamoto Y.
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.
Ann Rheum Dis. 2002 Feb;61(2):103-9.
Hossain A, Zheng CL, Kukita A, Kohashi O.
Balance of Th1/Th2 cytokines associated with the preventive effect of incomplete Freund's adjuvant on the development of adjuvant arthritis in LEW rats.
J Autoimmun. 2001 Dec;17(4):289-95.
Kukita T, Kukita A, Watanabe T, Iijima T.
Osteoclast differentiation antigen, distinct from receptor activator of nuclear factor kappa B, is involved in osteoclastogenesis under calcitonin-regulated conditions.
J Endocrinol. 2001 Jul;170(1):175-83.
Komine M, Kukita A, Kukita T, Ogata Y, Hotokebuchi T, Kohashi O.
Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture.
Bone. 2001 May;28(5):474-83.
Kukita T, Kukita A, Xu L, Watanabe T, Iijima T.
Kat1-antigen--a reliable immunological marker for identifying osteoclast precursors of rats: detection of subpopulations among precursors and initiation of osteoclastogenesis.
Histochem Cell Biol. 2001 Mar;115(3):215-22.
Kukita T, Kukita A, Iijima T.
[Osteoclast differentiation antigen involved in the induction of calcitonin escape phenomenon]
Kaibogaku Zasshi. 2000 Oct;75(5):433-8. Review.
Zaitsu M, Hamasaki Y, Matsuo M, Kukita A, Tsuji K, Miyazaki M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Ichimaru T, Kohashi O, Miyazaki S.
New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes.
Blood. 2000 Jul 15;96(2):601-9.
Kukita A, Kukita T, Ouchida M, Maeda H, Yatsuki H, Kohashi O.
Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis.
Blood. 1999 Sep 15;94(6):1987-97.
Ogata Y, Kukita A, Kukita T, Komine M, Miyahara A, Miyazaki S, Kohashi O.
A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2.
J Immunol. 1999 Mar 1;162(5):2754-60.
Harada H, Kukita T, Kukita A, Iwamoto Y, Iijima T.
Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: a possible role in direct interaction between osteoclast precursors.
Endocrinology. 1998 Sep;139(9):3967-75.
Kukita T, Kukita A, Xu L, Maeda H, Iijima T.
Successful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody.
Calcif Tissue Int. 1998 Aug;63(2):148-53.
Kukita T, Hata K, Kukita A, Iijima T.
Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis.
Calcif Tissue Int. 1998 Aug;63(2):140-2.
Kukita T, Kukita A, Harada H, Iijima T.
Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system.
Endocrinology. 1997 Oct;138(10):4384-9.
Kukita T, Nomiyama H, Ohmoto Y, Kukita A, Shuto T, Hotokebuchi T, Sugioka Y, Miura R, Iijima T.
Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow:its role in regulation of hematopoiesis and osteoclast recruitment.
Lab Invest. 1997 Mar;76(3):399-406.
Kukita T, Kukita A.
Osteoclast differentiation antigen.
Histol Histopathol. 1996 Jul;11(3):821-30. Review.
Xu LX, Kukita T, Kukita A, Otsuka T, Niho Y, Iijima T.
Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system.
J Cell Physiol. 1995 Dec;165(3):624-9.
Shin JH, Kukita A, Ohki K, Katsuki T, Kohashi O.
In vitro differentiation of the murine macrophage cell line BDM-1 into osteoclast-like cells.
Endocrinology. 1995 Oct;136(10):4285-92.
Kukita T, Kukita A, Nagata K, Maeda H, Kurisu K, Watanabe T, Iijima T.
Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor.
J Immunol. 1994 Dec 1;153(11):5265-73.
Maeda H, Kukita T, Akamine A, Kukita A, Iijima T.
Localization of osteopontin in resorption lacunae formed by osteoclast-like cells: a study by a novel monoclonal antibody which recognizes rat osteopontin.
Histochemistry. 1994 Oct;102(4):247-54.
Hata K, Kukita T, Akamine A, Kukita A, Kurisu K, Iijima T.
A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.
Histochemistry. 1994 Jun;101(5):347-54.
Kukita A, Kukita T, Shin JH, Kohashi O.
Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells.
Biochem Biophys Res Commun. 1993 Nov 15;196(3):1383-9.
Kukita A, Kukita T, Hata K, Kurisu K, Kohashi O.
Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells.
Bone Miner. 1993 Nov;23(2):113-27.
Kukita T, Nakao J, Hamada F, Kukita A, Inai T, Kurisu K, Nomiyama H.
Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system.
Bone Miner. 1992 Dec;19(3):215-23.
Kukita A, Harada H, Kukita T, Inai T, Matsuhashi S, Kurisu K.
Primary and secondary culture of rat ameloblasts in serum-free medium.
Calcif Tissue Int. 1992 Nov;51(5):393-8.
Kukita T, Kukita A, Hata K, Kurisu K.
12-O-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons.
Endocrinology. 1992 Feb;130(2):577-84.
Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR.
Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.
J Clin Invest. 1992 Jan;89(1):46-52.
Hata K, Kukita T, Akamine A, Kukita A, Kurisu K.
Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacunae on dentine.
Bone. 1992;13(2):139-46.
Inai T, Kukita T, Ohsaki Y, Nagata K, Kukita A, Kurisu K.
Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs.
Anat Rec. 1991 Feb;229(2):259-70.
Oreffo RO, Bonewald L, Kukita A, Garrett IR, Seyedin SM, Rosen D, Mundy GR.
Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts.
Endocrinology. 1990 Jun;126(6):3069-75.
Kukita A, Bonewald L, Rosen D, Seyedin S, Mundy GR, Roodman GD.
Osteoinductive factor inhibits formation of human osteoclast-like cells.
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3023-6.
Kukita A, Chenu C, McManus LM, Mundy GR, Roodman GD.
Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease.
J Clin Invest. 1990 Apr;85(4):1280-6.
Kukita A, Mukai T, Miyata T, Hori K.
The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes.
Eur J Biochem. 1988 Feb 1;171(3):471-8.
Kukita A, Yoshida MC, Fukushige S, Sakakibara M, Joh K, Mukai T, Hori K.
Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16.
Hum Genet. 1987 May;76(1):20-6.
Mesenchymal stem cells markedly suppress inflammatory bone destruction in rats with adjuvant-induced arthritis.
Lab Invest. 2014 Mar;94(3):286-96.
Kukita A, Kukita T.
Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis.
Future Oncol. 2013 Nov;9(11):1609-22.
Takahashi A, Kukita A, Li YJ, Zhang JQ, Nomiyama H, Yamaza T, Ayukawa Y, Koyano K, Kukita T.
Tunneling nanotube formation is essential for the regulation of osteoclastogenesis.
J Cell Biochem. 2013 Jun;114(6):1238-47.
Teramachi J, Kukita A, Qu P, Wada N, Li YJ, Nakamura S, Kukita T.
Adenosine blocks aminopterin-induced suppression of osteoclast differentiation.
J Bone Miner Metab. 2013 Jan;31(1):64-70.
Matsubara R, Kukita T, Ichigi Y, Takigawa I, Qu PF, Funakubo N, Miyamoto H, Nonaka K, Kukita A.
Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats.
PLoS One. 2012;7(10):e47930
Li YJ, Kukita A, Watanabe T, Takano T, Qu P, Sanematsu K, Ninomiya Y, Kukita T.
Nordihydroguaiaretic acid inhibition of NFATc1 suppresses osteoclastogenesis and arthritis bone destruction in rats.
Lab Invest. 2012 Dec;92(12):1777-87.
Kukita A, Ichigi Y, Takigawa I, Watanabe T, Kukita T, Miyamoto H.
Infection of RANKL-Primed RAW-D Macrophages with Porphyromonas gingivalis Promotes Osteoclastogenesis in a TNF-α-Independent Manner.
PLoS One. 2012;7(6):e38500. Epub 2012 Jun 18.
Katagiri N, Shobuike T, Chang B, Kukita A, Miyamoto H.
The human apoptosis inhibitor NAIP induces pyroptosis in macrophages infected with Legionella pneumophila.
Microbes Infect. 2012 14(13):1123-1132.
久木田明子，菖蒲池健夫，久木田敏夫
破骨細胞の分化と機能を制御する転写因子の役割
化学と生物. 2012 50(7):488-497.
Tsuji-Takechi K, Negishi-Koga T, Sumiya E, Kukita A, Kato S, Maeda T, Pandolfi PP, Moriyama K, Takayanagi H.
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2561-6.
Kukita A, Kukita T, Nagata K, Teramachi J, Li YJ, Yoshida H, Miyamoto H, Gay S, Pessler F, Shobuike T.
The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo.
Arthritis Rheum. 2011 Sep;63(9):2744-54.
Teramachi J, Kukita A, Li YJ, Ushijima Y, Ohkuma H, Wada N, Watanabe T, Nakamura S, Kukita T.
Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis.
Lab Invest. 2011 May;91(5):719-31.
Moller JC, Cron RQ, Young DW, Girschick HJ, Levy DM, Sherry DD, Kukita A, Saijo K, Pessler F.
Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: report of a new case and updated analysis of the literature.
Pediatr Rheumatol Online J. 2011 Feb 1;9(1):5.
Akiyama T, Miyamoto H, Fukuda K, Sano N, Katagiri N, Shobuike T, Kukita A, Yamashita Y, Taniguchi H, Goto M.
Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 May;109(5):669-76.
Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R.
Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7.
Miyamoto I, Liu J, Shimizu K, Sato M, Kukita A, Kukita T, Kondo R.
Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum.
Eur J Pharmacol. 2009 5;602(1):1-7.
Li YJ, Kukita A, Teramachi J, Nagata K, Wu Z, Akamine A, Kukita T.
A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats.
Lab Invest. 2009 Jan;89(1):26-37.
久木田明子
”特集/骨免疫学は偶然か必然か？“ OCZF/LRFとそのホモログの破骨細胞とリンパ球における機能
骨・関節・靱帯 第20巻第8号 2007
K. Ogawa, M. Mawatari, M. Komine, M. Shigematsu, M. Kitajima, A. Kukita, T. Hotokebuchi
Mature osteoclasts involved in joint destruction are present in the synovium from patients with rapidly destructive coxarthrosis.
J. Bone and Miner. Metab. 25(6):354-30 2007
T. Fukuda, K. Kanomata, J. Nojima, I. Urakawa, T. Suzawa, M. Imada, A. Kukita, R. Kamijo, T. Yamashita, T. Katagiri
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1.
Biochem. Biophys. Res. Comm. 353 p147-151 2007
Tang Q, Kukita T, Ushijima Y, Kukita A, Nagata K, Sandra F,Watanabe T, Toh K, Okuma Y, Kawasaki S, Rasubala L,Teramachi J,Miyamoto I, Wu Z, Iijima T
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds:successful supression of bone destruction accompanied with ajuvant-induced arthritis in rats.
Histochem. Cell Biol..125, NO.3, 215 2006
清水邦義、宮本以智子、塩野順、佐藤匡央、久木田明子、久木田敏夫、近藤隆一郎
マンネンタケ（Genoderma lucidum）エタノール抽出物による骨粗鬆症予防効果「機能性食品と薬理栄養」
日本機能性食品医用学会誌 VOL.4, NO.1, 29 2006年
Nakamura T, Kukita T, Shobuike T, Nagata K, Wu Z, Ogawa K, Hotokebuchi T, Kohashi O, Kukita A.
Inhibition of histone deacetylase suppresses osteoclastogenesis and bone destruction by inducing IFN-beta production.
J Immunol. 2005 Nov 1;175(9):5809-16.
Tang QY, Kukita T, Ushijima Y, Kukita A, Nagata K, Sandra F, Watanabe T, Toh K, Okuma Y, Kawasaki S, Rasubala L, Teramachi J, Miyamoto I, Wu Z, Iijima T.
Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats.
Histochem Cell Biol. 2005 Oct 5:1-11
Kukita T, Wada N, Kukita A, Kakimoto T, Sandra F, Toh K, Nagata K, Iijima T, Horiuchi M, Matsusaki H, Hieshima K, Yoshie O, Nomiyama H.
RANKL-induced DC-STAMP is essential for osteoclastogenesis.
J Exp Med. 2004 Oct 4;200(7):941-6. Epub 2004 Sep 27.
Toh K, Kukita T, Wu Z, Kukita A, Sandra F, Tang QY, Nomiyama H, Iijima T.
Possible involvement of MIP-1alpha in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis.
Lab Invest. 2004 Sep;84(9):1092-102.
Kukita T, Kukita A, Xu L, Toh K, Tang Q, Nomiyama H, Iijima T.
Extremely high expression of beta-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats.
J Electron Microsc (Tokyo). 2003;52(6):545-50.
Watanabe T, Kukita T, Kukita A, Wada N, Toh K, Nagata K, Nomiyama H, Iijima T.
Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL.
J Endocrinol. 2004 Jan;180(1):193-201.
Zheng CL, Ohki K, Hossain A, Kukita A, Satoh T, Kohashi O.
Complete Freund's adjuvant promotes the increases of IFN-gamma and nitric oxide in suppressing chronic arthritis induced by pristane.
Inflammation. 2003 Aug;27(4):247-55.
Rahman MM, Kukita A, Kukita T, Shobuike T, Nakamura T, Kohashi O.
Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages.
Blood. 2003 May 1;101(9):3451-9. Epub 2003 Jan 2.
Zheng CL, Hossain MA, Kukita A, Ohki K, Satoh T, Kohashi O.
Complete Freund's adjuvant suppresses the development and progression of pristane-induced arthritis in rats.
Clin Immunol. 2002 May;103(2):204-9.
Sakai H, Jingushi S, Shuto T, Urabe K, Ikenoue T, Okazaki K, Kukita T, Kukita A, Iwamoto Y.
Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells.
Ann Rheum Dis. 2002 Feb;61(2):103-9.
Hossain A, Zheng CL, Kukita A, Kohashi O.
Balance of Th1/Th2 cytokines associated with the preventive effect of incomplete Freund's adjuvant on the development of adjuvant arthritis in LEW rats.
J Autoimmun. 2001 Dec;17(4):289-95.
Kukita T, Kukita A, Watanabe T, Iijima T.
Osteoclast differentiation antigen, distinct from receptor activator of nuclear factor kappa B, is involved in osteoclastogenesis under calcitonin-regulated conditions.
J Endocrinol. 2001 Jul;170(1):175-83.
Komine M, Kukita A, Kukita T, Ogata Y, Hotokebuchi T, Kohashi O.
Tumor necrosis factor-alpha cooperates with receptor activator of nuclear factor kappaB ligand in generation of osteoclasts in stromal cell-depleted rat bone marrow cell culture.
Bone. 2001 May;28(5):474-83.
Kukita T, Kukita A, Xu L, Watanabe T, Iijima T.
Kat1-antigen--a reliable immunological marker for identifying osteoclast precursors of rats: detection of subpopulations among precursors and initiation of osteoclastogenesis.
Histochem Cell Biol. 2001 Mar;115(3):215-22.
Kukita T, Kukita A, Iijima T.
[Osteoclast differentiation antigen involved in the induction of calcitonin escape phenomenon]
Kaibogaku Zasshi. 2000 Oct;75(5):433-8. Review.
Zaitsu M, Hamasaki Y, Matsuo M, Kukita A, Tsuji K, Miyazaki M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Ichimaru T, Kohashi O, Miyazaki S.
New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes.
Blood. 2000 Jul 15;96(2):601-9.
Kukita A, Kukita T, Ouchida M, Maeda H, Yatsuki H, Kohashi O.
Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis.
Blood. 1999 Sep 15;94(6):1987-97.
Ogata Y, Kukita A, Kukita T, Komine M, Miyahara A, Miyazaki S, Kohashi O.
A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2.
J Immunol. 1999 Mar 1;162(5):2754-60.
Harada H, Kukita T, Kukita A, Iwamoto Y, Iijima T.
Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: a possible role in direct interaction between osteoclast precursors.
Endocrinology. 1998 Sep;139(9):3967-75.
Kukita T, Kukita A, Xu L, Maeda H, Iijima T.
Successful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody.
Calcif Tissue Int. 1998 Aug;63(2):148-53.
Kukita T, Hata K, Kukita A, Iijima T.
Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis.
Calcif Tissue Int. 1998 Aug;63(2):140-2.
Kukita T, Kukita A, Harada H, Iijima T.
Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system.
Endocrinology. 1997 Oct;138(10):4384-9.
Kukita T, Nomiyama H, Ohmoto Y, Kukita A, Shuto T, Hotokebuchi T, Sugioka Y, Miura R, Iijima T.
Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow:its role in regulation of hematopoiesis and osteoclast recruitment.
Lab Invest. 1997 Mar;76(3):399-406.
Kukita T, Kukita A.
Osteoclast differentiation antigen.
Histol Histopathol. 1996 Jul;11(3):821-30. Review.
Xu LX, Kukita T, Kukita A, Otsuka T, Niho Y, Iijima T.
Interleukin-10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast-like cells in rat bone marrow culture system.
J Cell Physiol. 1995 Dec;165(3):624-9.
Shin JH, Kukita A, Ohki K, Katsuki T, Kohashi O.
In vitro differentiation of the murine macrophage cell line BDM-1 into osteoclast-like cells.
Endocrinology. 1995 Oct;136(10):4285-92.
Kukita T, Kukita A, Nagata K, Maeda H, Kurisu K, Watanabe T, Iijima T.
Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor.
J Immunol. 1994 Dec 1;153(11):5265-73.
Maeda H, Kukita T, Akamine A, Kukita A, Iijima T.
Localization of osteopontin in resorption lacunae formed by osteoclast-like cells: a study by a novel monoclonal antibody which recognizes rat osteopontin.
Histochemistry. 1994 Oct;102(4):247-54.
Hata K, Kukita T, Akamine A, Kukita A, Kurisu K, Iijima T.
A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices.
Histochemistry. 1994 Jun;101(5):347-54.
Kukita A, Kukita T, Shin JH, Kohashi O.
Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells.
Biochem Biophys Res Commun. 1993 Nov 15;196(3):1383-9.
Kukita A, Kukita T, Hata K, Kurisu K, Kohashi O.
Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells.
Bone Miner. 1993 Nov;23(2):113-27.
Kukita T, Nakao J, Hamada F, Kukita A, Inai T, Kurisu K, Nomiyama H.
Recombinant LD78 protein, a member of the small cytokine family, enhances osteoclast differentiation in rat bone marrow culture system.
Bone Miner. 1992 Dec;19(3):215-23.
Kukita A, Harada H, Kukita T, Inai T, Matsuhashi S, Kurisu K.
Primary and secondary culture of rat ameloblasts in serum-free medium.
Calcif Tissue Int. 1992 Nov;51(5):393-8.
Kukita T, Kukita A, Hata K, Kurisu K.
12-O-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons.
Endocrinology. 1992 Feb;130(2):577-84.
Roodman GD, Kurihara N, Ohsaki Y, Kukita A, Hosking D, Demulder A, Smith JF, Singer FR.
Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone.
J Clin Invest. 1992 Jan;89(1):46-52.
Hata K, Kukita T, Akamine A, Kukita A, Kurisu K.
Trypsinized osteoclast-like multinucleated cells formed in rat bone marrow cultures efficiently form resorption lacunae on dentine.
Bone. 1992;13(2):139-46.
Inai T, Kukita T, Ohsaki Y, Nagata K, Kukita A, Kurisu K.
Immunohistochemical demonstration of amelogenin penetration toward the dental pulp in the early stages of ameloblast development in rat molar tooth germs.
Anat Rec. 1991 Feb;229(2):259-70.
Oreffo RO, Bonewald L, Kukita A, Garrett IR, Seyedin SM, Rosen D, Mundy GR.
Inhibitory effects of the bone-derived growth factors osteoinductive factor and transforming growth factor-beta on isolated osteoclasts.
Endocrinology. 1990 Jun;126(6):3069-75.
Kukita A, Bonewald L, Rosen D, Seyedin S, Mundy GR, Roodman GD.
Osteoinductive factor inhibits formation of human osteoclast-like cells.
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3023-6.
Kukita A, Chenu C, McManus LM, Mundy GR, Roodman GD.
Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease.
J Clin Invest. 1990 Apr;85(4):1280-6.
Kukita A, Mukai T, Miyata T, Hori K.
The structure of brain-specific rat aldolase C mRNA and the evolution of aldolase isozyme genes.
Eur J Biochem. 1988 Feb 1;171(3):471-8.
Kukita A, Yoshida MC, Fukushige S, Sakakibara M, Joh K, Mukai T, Hori K.
Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16.
Hum Genet. 1987 May;76(1):20-6.